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Corrected WBC Formula:
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Corrected WBC is an adjusted white blood cell count that accounts for the presence of nucleated red blood cells (NRBCs) in peripheral blood samples. This correction is necessary because automated cell counters may misidentify NRBCs as white blood cells, leading to falsely elevated WBC counts.
The calculator uses the corrected WBC formula:
Where:
Explanation: The formula adjusts the measured WBC count by removing the contribution of nucleated red blood cells, providing a more accurate representation of the true white blood cell count.
Details: Accurate WBC counting is crucial for diagnosing infections, inflammatory conditions, and hematological disorders. The correction is particularly important in neonatal samples, hematological malignancies, and other conditions where nucleated red blood cells may be present in peripheral blood.
Tips: Enter the measured WBC count in count/μL and the nucleated RBC percentage. Both values must be valid (WBC > 0, nucleated RBC ≥ 0).
Q1: When is corrected WBC calculation necessary?
A: Correction is needed when nucleated red blood cells are present in peripheral blood, typically in neonates, hematological disorders, or severe anemia.
Q2: How are nucleated RBCs reported?
A: Nucleated RBCs are usually reported as number per 100 white blood cells or as a percentage of total nucleated cells.
Q3: What is the clinical significance of corrected WBC?
A: Corrected WBC provides a more accurate assessment of the true white blood cell count, which is essential for proper diagnosis and treatment decisions.
Q4: Are there limitations to this correction?
A: The correction assumes accurate identification and counting of nucleated RBCs. Manual differential counts may be needed for verification.
Q5: How does this affect other hematological parameters?
A: While this correction adjusts WBC count, other parameters like hemoglobin and platelet counts are typically not affected by the presence of nucleated RBCs.